| 货号 | 11834-100mg |
| 描述 | Dioscin is a natural steroid saponin that was first isolated from plants used in herbal remedies.1 Early studies indicated that it inhibits proliferation and induces apoptosis in cancer cells.2,3 Dioscin has antioxidant activity that can alter cell signaling in cancer cells.4,5 It also induces autophagy prior to apoptosis in human lung cancer cell lines.6 |
| 别名 | Collettiside III; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Xu, X.-H.,Li, T.,Fong, C.M.V., et al. Saponins from Chinese Medicines as Anticancer Agents. Molecules 21(10), E1326 (2016). 2.Cai, J.,Liu, M.,Wang, Z., et al. Apoptosis induced by dioscin in Hela cells. Biol. Pharm. Bull. 25(2), 193-196 (2002). 3.Lee, K.J.,Oh, Y.C.,Cho, W.K., et al. Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assay. Evidence-Based Complementary and alternative Medicine (2015). 4.Zhou, Q.,Song, W., and Xiao, W. Dioscin induces demethylation of DAPK-1 and RASSF-1α genes via the antioxidant capacity, resulting in apoptosis of bladder cancer T24 cells. EXCLI J. 16, 101-112 (2017). 5.Hsieh, M.-J.,Tsai, T.-L.,Hsieh, Y.-S., et al. Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines. Arch. Toxicol. 87(11), 1927-1937 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 869.1 |
| 分子式 | C45H72O16 |
| CAS号 | 19057-60-4 |
| 稳定性 | ≥ 2 years |
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