| 货号 | 14595-10g |
| 描述 | Deferoxamine is a bacterial siderophore that chelates iron.1 It is used to experimentally inhibit iron-dependent prolyl hydroxylases (EC50 = 17.8 µM), thus preventing the degradation of isoforms of hypoxia inducible factor during normoxia.2,3,4 Deferoxamine has applications in diseases that are characterized by high levels of circulating iron, such as thalassemia major.5 |
| 别名 | Ba 33112;DFOM;DFX;NSC 644468; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Steinmetz, W.L.,Glick, M.R. and Oei, T.O. Modified aca method for determination of iron chelated by deferoxamine and other chelators. Clinical Chemistry 26(11), 1593-1597 (1980). 2.Theriault, J.R.,Felts, A.S.,Bates, B.S., et al. Discovery of a new molecular probe ML228: An activator of the hypoxia inducible factor (HIF) pathway. Bioorganic & Medicinal Chemistry Letters 22(1), 76-81 (2012). 3.Jaakkola, P.,Mole, D.R.,Tian, Y.M., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472 (2001). 4.Sandau, K.B.,Zhou, J.,Kietzmann, T., et al. Regulation of the hypoxia-inducible factor 1α by the inflammatory mediators nitric oxide and tumor necrosis factor-α in contrast to desferroxamine and phenylarsine oxide. The Journal of Biological Chemisty 276(43), 39805-39811 (2001). 5.Neufeld, E.J. Update on iron chelators in thalassemia. Hematology Am.Soc.Hematol.Educ.Program 2010, 451-455 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 656.8 |
| 分子式 | C25H48N6O8 • CH3SO3H |
| CAS号 | 138-14-7 |
| 稳定性 | ≥ 2 years |
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