Quinacrine analog 34
货号：
17733-10mg 基本售价：
9604.0 元 规格：
10 mg
产品信息
概述| 货号 | 17733-10mg |
| 描述 | Quinacrine (Item No. 15041) is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is considerably cytotoxic (LD50 = 2.5 µM).1 Quinacrine analog 34 is a derivative of quinacrine that was designed with an improved cell viability profile (LD50 = 27 µM) to inhibit autophagy.1 At a minimum concentration of 0.5 µM, this compound has been shown to increase the protein levels of the autophagy biomarker LC3-II and to induce lysosome deacidification.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, T.,Goodall, M.L.,Gonzales, P., et al. Synthesis of improved lysomotropic autophagy inhibitors. Journal of Medicinal Chemistry 58(7), 3025-3035 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 358.9 |
| 分子式 | C20H27ClN4 |
| CAS号 | 1411646-44-0 |
| 稳定性 | ≥ 2 years |
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