GSK2606414
货号：
17376-50mg 基本售价：
9604.0 元 规格：
50 mg
产品信息
概述| 货号 | 17376-50mg |
| 描述 | GSK2606414 is an orally available, selective protein kinase R-like ER kinase (PERK) inhibitor with an IC50 value of 0.4 nM.1 It can inhibit thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells and attenuates subcutaneous pancreatic human tumor xenograft growth in mice.1 Because PERK mediates the unfolded protein response pathway, which has roles in neurotoxicity and cancer, inhibition of PERK signaling has potential applications for the treatment of cancer and also cognitive degeneration. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hetz, C.,Chevet, E., and Harding, H.P. Targeting the unfolded protein response in disease. Drug Discovery 12, 703-719 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 451.4 |
| 分子式 | C24H20F3N5O |
| CAS号 | 1337531-36-8 |
| 稳定性 | ≥ 2 years |
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