Cariporide
货号：
16935-100mg 基本售价：
9604.0 元 规格：
100 mg
产品信息
概述| 货号 | 16935-100mg |
| 描述 | The sodium-hydrogen exchanger isoform-1 (NHE-1) is the predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.1 It plays an important role in the myocardial response to ischemia-reperfusion.2 Cariporide is a benzoylguanidine compound that inhibits NHE-1 with IC50 values ranging from 0.03-3.4 µM.1 It displays selectivity for NHE-1 over NHE-2, NHE-3, and NHE-5 (IC50s = 4.3-62, 1->100, and >30 µM, respectively).1 The cardioprotective efficacy of cariporide has been examined in clinical investigations of patients at risk for myocardial infarction.1,2 |
| 别名 | HOE 642; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Masereel, B.,Pochet, L., and Laeckmann, D. An overview of inhibitors of Na+/H+ exchanger. Eur. J. Med. Chem. 38(6), 547-554 (2003).
2.Karmazyn, M. The myocardial sodium-hydrogen exchanger (NHE) and its role in mediating ischemic and reperfusion injury. Keio J.Med. 47(2), 65-72 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 283.3 |
| 分子式 | C12H17N3O3S |
| CAS号 | 159138-80-4 |
| 稳定性 | ≥ 2 years |
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