ARM1
货号：
15865-100mg 基本售价：
9604.0 元 规格：
100 mg
产品信息
概述| 货号 | 15865-100mg |
| 描述 | Leukotriene A4(LTA4) hydrolase/aminopeptidase is a bifunctional zinc metalloenzyme that both catalyzes the synthesis of LTB4 (Item No. 20110) from LTA4 and cleaves the chemotactic peptide Pro-Gly-Pro.1,2 ARM1 is a thiazolamine that inhibits LTB4 synthesis in human neutrophils (IC50 = ~0.5 µM) and conversion of LTA4 to LTB4 by purified LTA4 hydrolase (Ki = 2.3 µM).3 ARM1 does not significantly affect the hydrolysis of Pro-Gly-Pro by LTA4hydrolase.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Haeggström, J.Z. Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis. The Journal of Biological Chemisty 279(49), 50639-50642 (2004).
2.Snelgrove, R.J.,Jackson, P.L.,Hardison, M.T., et al. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science 330, 90-94 (2010).
3.Stsiapanava, A.,Olsson, U.,Wan, M., et al. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proceedings of the National Academy of Sciences of the United States of America 111(11), 4227-4232 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 268.4 |
| 分子式 | C16H16N2S |
| CAS号 | 68729-05-5 |
| 稳定性 | ≥ 2 years |
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