Neoruscogenin
货号：
15567-10mg 基本售价：
9604.0 元 规格：
10 mg
产品信息
概述| 货号 | 15567-10mg |
| 描述 | Neoruscogenin is a natural sapogenin isolated from Butcher’s broom (R. rhizoma), which is traditionally used against chronic venous disorders.1 It is a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM).2 In mice, neoruscogenin up-regulates the expression of several RORα-inducible genes in the liver, when given at 3 mg/kg/d orally for seven days.2 |
| 别名 | 25(27)-Dehydroruscogenin; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Barbic, M.,Willer, E.A.,Rothenhöfer, M., et al. Spirostanol saponins and esculin from Rusci rhizoma reduce the thrombin-induced hyperpermeability of endothelial cells. Phytochemistry 90, 106-113 (2013).
2.Helleboid, S.,Haug, C.,Lamottke, K., et al. The identification of naturally occurring neoruscogenin as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (NR1F1). Journal of Biomolecular Screening 19(3), 399-406 (2014).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 428.6 |
| 分子式 | C27H40O4 |
| CAS号 | 17676-33-4 |
| 稳定性 | ≥ 2 years |
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