| 货号 | 13373-100mg |
| 描述 | 5-Azacytidine is an inhibitor of DNA methyltransferase, potentially serving to reverse epigenetic changes.1 It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer.2,3,4 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brueckner, B.,Boy, R.G.,Siedlecki, P., et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Research 65(14), 6305-6311 (2005). 2.Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008). 3.Lyko, F., and Brown, R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl. Cancer Inst. 97(20), 1498-1506 (2005). 4.Stresemann, C.,Brueckner, B.,Musch, T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 370.3 |
| 分子式 | C14H18N4O8 |
| CAS号 | 10302-78-0 |
| 稳定性 | ≥ 2 years |
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