RG-108
货号：
13302-100mg 基本售价：
9604.0 元 规格：
100 mg
产品信息
概述| 货号 | 13302-100mg |
| 描述 | DNA methylation regulates gene expression in normal and malignant cells. RG-108 is a non-nucleoside DNA methyltransferase inhibitor (IC50 = 115 nM in vitro).1 It significantly reduces the methylation of genomic DNA in cells at 10 μM without detectable toxicity, distinguishing it from nucleoside-based inhibitors like 5-azacytidine.2,1 Further, RG-108 inhibits DNA methyltransferase activity by blocking the enzyme active site.2 Through these actions, RG-108 demethylates and reactivates epigenetically silenced tumor suppressor genes.1 |
| 别名 | N-Phthalyl-L-Tryptophan; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Brueckner, B.,Boy, R.G.,Siedlecki, P., et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Research 65(14), 6305-6311 (2005).
2.Stresemann, C.,Brueckner, B.,Musch, T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 334.3 |
| 分子式 | C19H14N2O4 |
| CAS号 | 48208-26-0 |
| 稳定性 | ≥ 2 years |
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