Trimidox
货号：
10009083-100mg 基本售价：
9604.0 元 规格：
100 mg
产品信息
概述| 货号 | 10009083-100mg |
| 描述 | Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is a common target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation.1 Trimidox is a specific ribonucleotide reductase inhibitor that reduces levels of dGTP and dCTP in HL-60 cells, inducing apoptosis via activation of caspases without altering the cell cycle distribution.1,2 Trimidox inhibits growth of human promyelocytic leukemia HL-60 cells with an IC50 value of 35 µM.1 |
| 别名 | VF 233; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Szekeres, T.,Fritizer, M.,Strobl, H., et al. Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells. Blood 84(12), 4316-4321 (1994).
2.Kanno, S.I.,Uwai, K.,Tomizawa, A., et al. Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells. Basic & Clinical Pharmacology & Toxicology 98, 44-50 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 184.2 |
| 分子式 | C7H8N2O4 |
| CAS号 | 95933-74-7 |
| 稳定性 | ≥ 2 years |
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