| 货号 | 2202/50 |
| 别名 | 3-[3-[[2-(3,4-Dimethoxyphenyl)ethyl |
| 供应商 | Tocris |
| 生物活性 | Bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells (EC50 = 480 nM) and Purkinje fibres. Displays negative chronotropic activity in isolated guinea pig atria (EC50 of 13.4 μM). |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 493.04 |
| 分子式 | C26H36N2O5.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 91940-87-3 |
| 参考文献 | Romanelliet al (2005) Design, synthesis and preliminary biological evaluation of zatebradine analogues as potential blockers of the hyperpolarization-activated current. Bioorg.Med.Chem. 13 1211. PMID: 15670930. Goethalset al (1993) Use-dependent block of the pacemaker current I(f) in rabbit sinoatrial node cells by zatebradine (UL-FS 49). On the mode of action of sinus node inhibitors. Circulation 88 2389. PMID: 8222132. Van Bogaertet al (1990) Use- and frequency-dependent blockade by UL-FS 49 of the if pacemaker current in sheep cardiac Purkinje fibres. Eur.J.Pharmacol. 187 241. PMID: 2272362. |