| 货号 | 1040/50 |
| 别名 | (1,2,5,6-Tetrahydropyridin-4-yl)met |
| 供应商 | Tocris |
| 生物活性 | A selective, competitive GABAA-ρ antagonist with only minimal effects on GABAA and GABAB receptors (Kb values are 2.1 μM (antagonist), 320 μM (antagonist) and EC50 ~ 500 μM (weak agonist) respectively). Displays 8-fold selectivity for human recombinant ρ1 receptors over ρ2 receptors. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 161.14 |
| 分子式 | C6H12NO2P |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 182485-36-5 |
| 参考文献 | Xuet al (2009) The involvement of GABA-C receptors in paired pulse depression of inhibitory postsynaptic currents in rat hippocampal CA1 pyramidal neurons. Exp.Neurol. 216 243. PMID: 19100735. Chebibet al (1998) GABAC receptor antagonists differentiate between human r1 and r2 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 357 227. PMID: 9797041. Murataet al (1996) The first selective antagonist for a GABAc receptor. Bioorg.Med.Chem.Lett. 62073. Ragozzinoet al (1996) Design and in vitro pharmacology of a selective γ-aminobutyric acidc receptor antagonist. Mol.Pharmacol. 50 1024. PMID: 8863850. |