| 货号 | 3666/50 |
| 别名 | (R)-[[2-(6-Amino-9H-purin-9-yl)-1-m |
| 供应商 | Tocris |
| 生物活性 | Selectively inhibits HIV reverse transcriptase (RNA-dependent DNA polymerase). Prevents cytotoxicity in SIV-infected C-8166 cells in vitro (IC50 = 1.5 μM). Antiviral agent. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 287.21 |
| 分子式 | C9H14N5O4P |
| 可溶性/溶解性 | Soluble to 100 mM in 1.1eq. NaOH and to 10 mM in DMSO |
| CAS号 | 147127-20-6 |
| 参考文献 | Suoet al (1998) Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-phosphonylmethoxypropyl)adenine. J.Biol.Chem. 273 27250. PMID: 9765248. Van Rompayet al (1996) 9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques. Antimicrob.Agents Chemother. 40 2586. PMID: 8913470. Tsaiet al (1995) Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine. Science 270 1197. PMID: 7502044. |