| 货号 | 3815/50 |
| 别名 | 2-Chloro-N-[(1R)-1-(3-methoxyphenyl |
| 供应商 | Tocris |
| 生物活性 | Positive allosteric modulator and allosteric agonist of the human calcium-sensing receptor (hCaSR). Exhibits calcimimetic activity. Has the ability to restore function to hCaSR mutants that cause familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT). Exerts a suppressive effect on parathyroid (PT) hormone secretion; inhibits PT cell proliferation in rats with renal insufficiency. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 340.29 |
| 分子式 | C18H22ClNO.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 177172-49-5 |
| 参考文献 | Ying Lin Luet al (2009) Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor. J.Pharmacol.Exp.Ther. 331 775. PMID: 19759318. Foxet al (1999) NPS R-568: a type II calcimimetic compound that acts on parathyroid cell calcium receptor of rats to reduce plasma levels of parathyroid hormone and calcium. J.Pharmacol.Exp.Ther. 290 473. PMID: 10411552. Wadaet al (1997) The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. J.Clin.Invest. 100 2977. PMID: 9399943. |