PIT 1 (50 MG)
货号：
4168/50 基本售价：
9597.2 元 规格：
50 mg
产品信息
概述| 货号 | 4168/50 |
| 别名 | N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide |
性能| 供应商 | Tocris |
| 生物活性 | Selective PIP3 antagonist. Blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03 μM). Inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Exhibits antitumor activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 351.76 |
| 分子式 | C14H10ClN3O4 |
| 可溶性/溶解性 | Soluble to 75 mM in DMSO |
| 参考文献 | Miaoet al (2010) Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proc.Natl.Acad.Sci. 1072012. |
