| 货号 | 1065/50 |
| 别名 | N-(Methyl-4-(2-cyanophenyl)piperazi |
| 供应商 | Tocris |
| 生物活性 | A potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. Induces synaptic translocation of CaMK II to postsynaptic sites in cultured prefrontal cortical neurons. Centrally active in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >99 % |
| 计算分子量 | 450.49 |
| 分子式 | C20H22N4O.C4H4O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| 参考文献 | Guet al (2006) Activation of dopamine D4 receptors induces synaptic translocation of Ca2+/calmodulin-dependent protein kinase II in cultured prefrontal cortical neurons. Mol.Pharmacol. 69 813. PMID: 16365279. Clifford and Waddington (2000) Topographically based search for an "Ethogram" among a series of novel D4 dopamine receptor agonists and antagonists. Neuropsychopharmacology 22 538. PMID: 10731629. Glaseet al (1997) Substituted [(4-phenylpiperazinyl)methyl]benzamides: selective dopamine D4 agonists. J.Med.Chem. 40 1771. PMID: 9191952. |