| 货号 | 1269/50 |
| 别名 | (Z)-3-(4-Iodophenyl)-2-mercapto-2-p |
| 供应商 | Tocris |
| 生物活性 | Selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). Targets the calcium binding sites of calpain. Demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 306.12 |
| 分子式 | C9H7IO2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Squieret al (1999) Calpain and calpastatin regulate neutrophil apoptosis. J.Cell Physiol. 178 311. PMID: 9989777. Waterset al (1997) Calpains mediate calcium chloride influx during the late phase of cell injury. J.Pharmacol.Exp.Ther. 283 1177. PMID: 9399991. Wanget al (1996) An alpha-mercaptoacrylic acid derivative is a selective nonpeptide cell-permeable calpain inhibitor and is neuroprotective. Proc.Natl.Acad.Sci.U.S.A. 93 6687. PMID: 8692879. |