| 货号 | 3133/50 |
| 别名 | 4-Methoxy-3-(2-phenylethoxy)-N,N-di |
| 供应商 | Tocris |
| 生物活性 | Potent and selective σ1 receptor antagonist (Ki = 0.86 nM) that displays > 55-fold selectivity over σ2 receptors and > 6000-fold selectivity over D1, D2, 5-HT1A, 5-HT2 and PCP receptors. Exhibits reversible binding (Kd = 1.2 nM) and displays antipsychotic activity in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 391.97 |
| 分子式 | C23H33NO2.HCl |
| 可溶性/溶解性 | Soluble to 25 mM in water and to 100 mM in DMSO |
| CAS号 | 149409-57-4 |
| 参考文献 | Tanakaet al (1995) Characteristics of binding of [3H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. Naunyn Schmied.Arch.Pharmacol. 351244. Chakiet al (1994) NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain. Eur.J.Pharmacol. 251 R1. PMID: 8137864. Okuyamaet al (1993) NE-100, a novel sigma receptor ligand: in vivo tests. Pharmacol.Letts. 53PL285. |