| 货号 | 1591/50 |
| 别名 | 5-Chloro-N-(cyclopropylmethyl)-2-me |
| 供应商 | Tocris |
| 生物活性 | Selective, non-peptide corticotropin-releasing factor1(CRF1) receptor antagonist (Ki = 1.7 nM); has no activity at CRF2 receptors. Blocks behavioral seizures in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 470.66 |
| 分子式 | C18H20Cl4N4.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in ethanol and to 100 mM in DMSO |
| CAS号 | 184241-44-9 |
| 参考文献 | McCarthyet al (1999) Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. Curr.Pharm.Des. 5 289. PMID: 10213797. Baramet al (1997) The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 770 89. PMID: 9372207. Chenet al (1996) Design and synthesis of a series of non-peptide high-affinity human corticotropin-releasing factor1 receptor antagonists. J.Med.Chem. 39 4358. PMID: 8893829. |