| 货号 | 4564/50 |
| 别名 | 1-(2,3-Dihydro-7-methoxy-1,4-benzot |
| 供应商 | Tocris |
| 生物活性 | Ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 540.67 |
| 分子式 | C25H32N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Yeet al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53. PMID: 21989257. Chenet al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915. PMID: 17994112. Huntet al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431. PMID: 17313373. |