| 货号 | 3503/50 |
| 别名 | 5-[[3-Dimethylamino)propyl]amino]-3 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of Hdm2 ubiquitin ligase (E3). Blocks Hdm2-mediated ubiquitylation and proteasomal degradation of p53; activates p53-dependent transcription. Induces apoptosis in several tumor cell lines that express wild-type p53 such as LOX-IMVI, A549, HT1080 and U2OS. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 414.33 |
| 分子式 | C18H23N5O2.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in water and to 10 mM in DMSO |
| CAS号 | 502137-98-6 |
| 参考文献 | Yanget al (2009) Targeting the ubiquitin-proteasome system for cancer therapy. Cancer Sci. 100 24. PMID: 19037995. Kitagakiet al (2008) Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol.Cancer Ther. 7 2445. PMID: 18723490. |