| 货号 | 3113/50 |
| 别名 | 6-Chloro-2-N-ethyl-4-methyl-4-pheny |
| 供应商 | Tocris |
| 生物活性 | Potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2orβ3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 337.24 |
| 分子式 | C17H17ClN2O.HCl |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming |
| CAS号 | 56776-32-0 |
| 参考文献 | Girardet al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery. Proc.Natl.Acad.Sci. 10520505. Hamonet al (2003) The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit. Neuropharmacology 45 293. PMID: 12871647. |