| 货号 | 5472/50 |
| 别名 | rel-N2-[(1R,2S)-2-Aminocyclohexyl]- |
| 供应商 | Tocris |
| 生物活性 | Potent cdk1 inhibitor (IC50 = 25 nM). Reduces Akt phosphorylation and increases mitochondrial damage in leukemia cells in vitro in combination with LY 294002. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 458.82 |
| 分子式 | C19H24ClN7.2HCl |
| 可溶性/溶解性 | Soluble to 50 mM in water and to 100 mM in DMSO |
| 参考文献 | Yuet al (2013) The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process. Cancer Res. 63 1822. PMID: 12702569. Furetet al (2000) Structure-based design of potent CDK1 inhibitors derived from olomoucine. J.Comput.Aided Mol.Des. 14 403. PMID: 10896313. |