| 货号 | 5236/50 |
| 别名 | (1R,5S)-1,2,3,4,5,6-Hexahydro-3-[2- |
| 供应商 | Tocris |
| 生物活性 | High affinity and subtype selective α6β2 and α4β2 partial agonist (Ki values are 12 and 26nM for rat α6β2 and α4β2 receptors respectively). Has low affinity for α3β4 and α7 receptors (Ki values are 4.8 and 13 μM for human α3β4 and rat α7 receptors respectively). Stimulates dopamine release from striatal slices in vitro. Attenuates nicotine-induced self-administration and conditional place preference in rats. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 406.52 |
| 分子式 | C24H30N4O2 |
| 可溶性/溶解性 | Soluble to 20 mM in water and to 100 mM in DMSO |
| 参考文献 | Salaet al (2013) CC4, a dimer of cytisine, is a selective partial agonist at α4β2/α6β2 nAChR with improved selectivity for tobacco smoking cessation. Br.J.Pharmacol. 168 835. PMID: 22957729. Rigantiet al (2005) Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells. Br.J.Pharmacol. 146 1096. PMID: 16273122. Carbonnelleet al (2003) Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes. Eur.J.Pharmacol. 471 85. PMID: 12818695. |