| 货号 | 0760/50 |
| 别名 | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetr |
| 供应商 | Tocris |
| 生物活性 | An analog of retinoic acid that acts as a selective RARα agonist (EC50 values are 0.3, 8.6 and 13 nM for RARα, RARβ and RARγ respectively). Significantly induces IL-4, IL-5 and IL-13 and inhibits IL-12 and IFNγ synthesis, and induces cell differentiation with over 7 times the activity of retinoic acid in vitro. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 351.44 |
| 分子式 | C22H25NO3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 100 mM in ethanol |
| CAS号 | 102121-60-8 |
| 参考文献 | Wanget al (2011) Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1. Proc.Natl.Acad.Sci.U.S.A. 108 18283. PMID: 21990348. Chartonet al (2009) Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives. Bioorg.Med.Chem.Lett. 19 489. PMID: 19058965. Dawsonet al (2008) The retinoic acid receptor-α mediates human T-cell activation and Th2 cytokine and chemokine production. BMC Immunol. 9 16. PMID: 18416830. Kagechikaet al (1988) Retinobenzoic acids. 1. Structure-activity relationships of aromatic amides with retinoidal activity. J.Med.Chem. 31 2182. PMID: 3184125. |