| 货号 | 0581/50 |
| 别名 | 2-[(4-Phenylpiperazin-1-yl)methyl]- |
| 供应商 | Tocris |
| 生物活性 | Very potent ligand for α1 sites (Ki for displacement of prazosin = 0.2 nM). Displays different binding properties for each α1 subtype (pKi values are 8.74, 9.44 and 9.57 for α1B,α1Dandα1A adrenoceptors respectively). Also binds to 5-HT1A sites (Ki = 50 nM). |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 419.48 |
| 分子式 | C23H25N5O3 |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO with gentle warming |
| 参考文献 | Romeoet al (2003) New pyrimido[5,4-b]indoles as ligands for α1-adrenoceptor subtypes. J.Med.Chem. 46 2877. PMID: 12825930. Russoet al (1991) Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective α1 adrenoceptor ligands. J.Med.Chem. 34 1850. PMID: 1648138. |