| 货号 | 0775/50 |
| 别名 | cis-(+)-5-Methoxy-1-methyl-2-(di-N- |
| 供应商 | Tocris |
| 生物活性 | D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay); displays preferential activity at central dopamine autoreceptors. Stimulates a marked acceleration of dopamine synthesis and turnover. Produces locomotor stimulation. Exhibits little or no activity at central noradrenalin and 5-HT receptors. Also D3 partial agonist. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 计算分子量 | 391.51 |
| 分子式 | C18H29NO.C4H4O4 |
| 可溶性/溶解性 | Soluble to 50 mM in water |
| CAS号 | 95999-12-5 |
| 参考文献 | Hall and Strange (1997) Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors. Br. J. Pharmacol. 121 731. PMID: 9208141. Griffonet al (1995) The preferential dopamine D3 receptor ligand, (+)-UH 232, is a partial agonist. Eur.J.Pharmacol. 282 R3. PMID: 7498261. Svenssonet al (1986) (+)-AJ 76 and (+)-UH 232: central stimulants acting as preferential dopamine autoreceptor antagonists. Naunyn Schmiedebergs Arch.Pharmacol. 334 234. PMID: 2880302. Johanssonet al (1985) Novel dopamine receptor agonists and antagonists with preferential action on autoreceptors. J.Med.Chem. 28 1049. PMID: 3927002. |