Nanchangmycin
货号：
21679-25mg 基本售价：
9562.0 元 规格：
25 mg
产品信息
概述| 货号 | 21679-25mg |
| 描述 | Nanchangmycin is a polyether ionophore antibiotic produced by S. nanchangensis NS3226 that has insecticidal and in vitro antibacterial properties.1,2 Nanchangmycin exhibits antiviral properties against Zika virus (ZIKV) by blocking viral entry in vitro in a spectrum of cell types, including U2OS, human microvascular endothelial cells, and placental Jeg3 cells (IC50s = 100, 400, and 970 nM, respectively).3 Nanchangmycin also blocks ZIKV entry into primary cells, including extravillous trophoblasts, human primary uterine microvascular endothelial cells, human umbilical vein endothelial cells, and murine primary midbrain neuron-glia cultures.3 Efficacy of nanchangmycin extends to other viruses where it blocks entry into U2OS cells by West Nile, dengue, Sindbis, and chikungunya viruses.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sun, Y.,Zhou, X.,Dong, H., et al. A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin. Chem. Biol. 10(5), 431-441 (2003).
2.Liu, T.,Lin, X.,Zhou, X., et al. Mechanism of thioesterase-catalyzed chain release in the biosynthesis of the polyether antibiotic nanchangmycin. Chem. Biol. 15(5), 449-458 (2008).
3.Rausch, K.,Hackett, B.,Weinbren, N.R., S., et al. Screening bioactives reveals nanchangmycin as a broad spectrum antiviral active against Zika virus. Cell Rep. 18(3), 804-815 (2017).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 889.1 |
| 分子式 | C47H77O14 • Na |
| CAS号 | 65101-87-3 |
| 稳定性 | ≥ 2 years |
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