A-77-01
货号：
18396-25mg 基本售价：
9562.0 元 规格：
25 mg
产品信息
概述| 货号 | 18396-25mg |
| 描述 | A-77-01 is a potent inhibitor of the TGF-β1 receptor ALK5 (IC50 = 25 nM).1 It has no effects on BMP-regulated transcriptional activity or MAPK pathways. A-77-01 efficiently prevents the growth inhibitory effects of TGF-β on lung epithelial Mv1Lu cells.1 It completely blocks phosphorylation of SMAD2 by TGF-β in human keratinocyte HaCaT cells at 1 µM. A-77-01 prevents morphological and gene expression changes characteristic of epithelial-to-mesenchymal transition in NMuMG cells treated with TGF-β.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tojo, M.,Hamashima, Y.,Hanyu, A., et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer Science 96(11), 791-800 (2005).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 286.3 |
| 分子式 | C18H14N4 |
| CAS号 | 607737-87-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
