TSI-01
货号：
17628-25mg 基本售价：
9562.0 元 规格：
25 mg
产品信息
概述| 货号 | 17628-25mg |
| 描述 | Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 µM for human LPCAT2 and LPCAT1, respectively).1 At 60 µM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tarui, M.,Shindou, H.,Kumagai, K., et al. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. Journal of Lipid Research 55(7), 1386-1396 (2014).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 328.2 |
| 分子式 | C14H11Cl2NO4 |
| CAS号 | 704878-75-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
