CD2665
货号：
16031-50mg 基本售价：
9562.0 元 规格：
50 mg
产品信息
概述| 货号 | 16031-50mg |
| 描述 | CD2665 is a selective retinoic acid receptor (RAR)β and RARγ antagonist (Kds = 110, 306, and > 2,250 nM for RARγ, RARβ, and RARα, respectively, with no binding at RXRα).1 At 10-7 M, it has been used to abrogate retinoic acid (Item No. 11017)-induced antiproliferative and antidifferentiative effects on sebocyte growth.1 This compound has been used in animal and in vitro cell models to explore the role of retinoid signaling in a number of biological processes including memory formation and tumor proliferation.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kim, M.J.,Ciletti, N.,Michel, S., et al. The role of specific retinoid receptors in sebocyte growth and differentiation in culture. Journal of Investigative Dermatology 114, 349-353 (2000).
2.Alfos, S.,Boucheron, C.,Pallet, V., et al. A retinoic acid receptor antagonist suppresses brain retinoic acid receptor overexpression and reverses a working memory deficit induced by chronic ethanol consumption in mice. Alcholism: Clinical and Experimental Research 25(10), 1506-1514 (2001).
3.Marikar, Y.,Wang, Z.Q.,Duell, E.A., et al. Retinoic acid receptors regulate expression of retinoic acid 4-hydroxylase that specifically inactivates all-trans retinoic acid in human keratinocyte HaCaT cells. Journal of Investigative Dermatology 111(3), 434-439 (1998).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 486.6 |
| 分子式 | C31H34O5 |
| CAS号 | 170355-78-9 |
| 稳定性 | ≥ 2 years |
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