LY2157299
货号：
15312-50mg 基本售价：
9562.0 元 规格：
50 mg
产品信息
概述| 货号 | 15312-50mg |
| 描述 | LY2157299 is a small molecule inhibitor of the TGF-β receptor type 1 kinase (IC50 = 56 nM).1 It has been used to study the role of TGF-β signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts.2 LY2157299 has also been shown to inhibit the migration and tumor growth of hepatocellular carcinoma cell lines by disrupting Smad-2 phosphorylation.3 |
| 别名 | Galunisertib; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mundla, S.R. A pyridin quinolin substituted pyrrolo [1,2-B] pyrazole monohydrate as TGFβinhibitor. PCT/US2006/025377, 1-13 (2014).
2.Bhola, N.E.,Balko, J.M.,Dugger, T.C., et al. TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer. Journal of Clinical Investigation 123(3), 1348-1358 (2013).
3.Dituri, F.,Mazzocca, A.,Peidrò, F.J., et al. Differential inhibition of the TGF-β signaling pathway in HCC cells using the small molecule inhibitor LY2157299 and the D10 monoclonal antibody against TGF-β receptor type II. PLoS One 8(6), e67109 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 369.4 |
| 分子式 | C22H19N5O |
| CAS号 | 700874-72-2 |
| 稳定性 | ≥ 2 years |
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