| 货号 | 14866-25mg |
| 描述 | Silodosin is a potent α1A-adrenoceptor antagonist (Ki = 0.036 nM).1,2 It shows selectivity for the prostatic adrenoceptor.1,3 As a result, it is effective against lower urinary tract symptoms associated with benign prostatic hyperplasia.4,5 |
| 别名 | KMD-3213; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Moriyama, N.,Akiyama, K.,Murata, S., et al. KMD-3213, a novel α1A-adrenoceptor antagonist, potently inhibits the functional α1-adrenoceptor in human prostate. European Journal of Pharmacology 331, 39-42 (1997). 2.Li, M.Y.,Tsai, K.C. and Xia, L. Pharmacophore identification of α1A-adrenoceptor antagonists. Bioorganic & Medicinal Chemistry Letters 15(3), 657-664 (2005). 3.Akiyama, K.,Hora, M.,Tatemichi, S., et al. KMD-3213, a uroselective and long-acting α1a-adrenoceptor antagonist, tested in a novel rat model. Journal of Pharmacology and Experimental Therapeutics 291(1), 81-91 (1999). 4.Ding, H.,Du, W.,Hou, Z.Z., et al. Silodosin is effective for treatment of LUTS in men with BPH: A systematic review. Asian Journal of Andrology 15(1), 121-128 (2013). 5.Yoshida, M.,Kudoh, J.,Homma, Y., et al. Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia. Clinical Interventions in Aging 6, 161-172 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 495.5 |
| 分子式 | C25H32F3N3O4 |
| CAS号 | 160970-54-7 |
| 稳定性 | ≥ 2 years |
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