ML-297
货号：
14792-25mg 基本售价：
9562.0 元 规格：
25 mg
产品信息
概述| 货号 | 14792-25mg |
| 描述 | G protein-regulated inwardly rectifying potassium (GIRK1-4) channels are a family of Kir3.1-Kir3.4 ion channels that modulate cell excitability. The four different GIRK subunits are composed in different homo- and heterotetrameric combinations, which are expressed with regional specificity throughout the central nervous system and in the periphery.1 ML-297 is a selective GIRK1/2 activator (EC50s = 0.16 and 1.8 μM for GIRK1/2 and GIRK1/4, respectively, and is completely inactive at GIRK2/3).1,2 In two different mouse models of epilepsy, ML-297 at 60 mg/kg was shown to delay seizure onset and to prevent convulsions.1 |
| 别名 | CID-56642816;VU0456810; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kaufmann, K.,Romaine, I.M.,Days, E., et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem.Neurosci. 4(9), 1278-1286 (2013).
2.Wen, W.,Wu, W.,Romaine, I.M., et al. Discovery of molecular switches within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorganic & Medicinal Chemistry Letters 23(16), 4562-4566 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 328.3 |
| 分子式 | C17H14F2N4O |
| CAS号 | 1443246-62-5 |
| 稳定性 | ≥ 2 years |
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