Onalespib
货号：
10655-25mg 基本售价：
9562.0 元 规格：
25 mg
产品信息
概述| 货号 | 10655-25mg |
| 描述 | Onalespib is a selective inhibitor of Hsp90 (IC50 = 18 nM).1 It induces the degradation of specific Hsp90 client proteins, including mutant EGFR, for up to seven days in tumor cell lines in vitro and up to three days in vivo.1,2 Onalespib is retained in tumor xenografts and is efficacious in a range of xenograft models.2 |
| 别名 | AT-13387; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Woodhead, A.J.,Angove, H.,Carr, M.G., et al. Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design. Journal of Medicinal Chemistry 53, 5956-5969 (2010).
2.Graham, B.,Curry, J.,Smyth, T., et al. The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer. Cancer Sci. 103(3), 522-527 (2012).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 409.5 |
| 分子式 | C24H31N3O3 |
| CAS号 | 912999-49-6 |
| 稳定性 | ≥ 2 years |
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