| 货号 | 9002504-5mg |
| 描述 | Prostaglandin D2(PGD2; Item No. 12010), the major eicosanoid product of mast cells in the immune system, is also produced in the brain where it is involved in sleep regulatory mechanisms.1,2 Further pharmacological actions include inhibition of platelet aggregation, relaxation of vascular smooth muscle, and regulation of reproductive development.3 Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release.4 Peripheral, paracrine actions of dopamine include the control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.2,5 Catecholamines are known to stimulate prostanoid synthesis by acting as co-substrates.6PGD2 dopamine is a conjugate of the neurotransmitter dopmaine and PGD2. It can be used to study the biological function of PGD2 in the brain and periphery. |
| 别名 | PGD2DA;PGD2Dopamine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Roberts, L.J., II, and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30, 383-400 (1985). 2.Hayaishi, O. Functional genomics of sleep and circadian rhythm invited review: Molecular genetic studies on sleep-wake regulation, with special emphases on the prostaglandin D2 system. J. Appl. Physiol. 92(2), 863-868 (2015). 3.Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35, 277-300 (1988). 4.Missale, C.,Nash, S.R.,Robinson, S.W., et al. Dopamine receptors: From structure to function. Physiol. Rev. 78(1), 190-225 (1998). 5.Garza, J.H.H., and Carr, D.J.J. Neuroendocrine peptide receptors on cells of the immune system. Chem. Immunol. 69, 132-154 (1997). 6.Alanko, J.,Riutta, A., and Vapaatalo, H. Effects of catecholamines on eicosanoid synthesis with special reference to prostanoid/leukotriene ratio. Free Radical Biology & Medicine 13, 677-688 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 487.6 |
| 分子式 | C28H41NO6 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |