Tazarotenic Acid
货号：
21367-50mg 基本售价：
9520.0 元 规格：
50 mg
产品信息
概述| 货号 | 21367-50mg |
| 描述 | Tazarotenic acid is an active metabolite of tazarotene, an acetylenic retinoid prodrug that induces epidermal hyperplasia with an ED50 value of 100 nM.1,2 Tazarotenic acid selectively binds retinoic acid receptors (RAR-β and RAR-γ) in vitro.1 It has a relatively short elimination half-life of one to two hours and is metabolized by cytochrome P450 (CYP) isoforms CYP2C8, CYP26A1, and CYP26B1.1,3 |
| 别名 | AGN 190299; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Chandraratna, R.A. Tazarotene-first of a new generation of receptor-selective retinoids.. Br. J. Dermatol. 135(Suppl 49), 18-25 (1996).
2.Thacher, S.M.,Standeven, A.M.,Athanikar, J., et al. Receptor specificity of retinoid-induced epidermal hyperplasia: Effect of RXR-selective agonists and correlation with topical irritation. Journal of Pharmacology and Experimental Therapeutics 282(2), 528-534 (1997).
3.Foti, R.S.,Diaz, P., and Douguet, D. Comparison of the ligand binding site of CYP2C8 with CYP26A1 and CYP26B1: A structural basis for the identification of new inhibitors of the retinoic acid hydroxylases. J. Enzyme Inhib. Med. Chem. 31(Sup2), 148-161 (2016).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 323.4 |
| 分子式 | C19H17NO2S |
| CAS号 | 118292-41-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
