XY1
货号：
17518-50mg 基本售价：
9520.0 元 规格：
50 mg
产品信息
概述| 货号 | 17518-50mg |
| 描述 | Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.1,2 SGC707 (Item No. 17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM.3 It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Tang, J.,Gary, J.D.,Clarke, S., et al. PRMT3, a type I protein arginine N-methyltransferase that differs from PRMT1 in its oligomerization, subcellular localization, substrate specificity, and regulation. The Journal of Biological Chemisty 273(27), 16935-16945 (1998).
2.Wolf, S.S. The protein arginine methyltransferase family: An update about function, new perspectives and the physiological role in humans. Cellular and Molecular Life Sciences 66, 2109-2121 (2009).
3.Kaniskan, H.Ü.,Szewczyk, M.M.,Yu, Z., et al. A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem. 127, 1-34 (2015).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 297.4 |
| 分子式 | C17H19N3O2 |
| CAS号 | 1624117-53-8 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
