A-443654
货号：
16499-5mg 基本售价：
9520.0 元 规格：
5 mg
产品信息
概述| 货号 | 16499-5mg |
| 描述 | Three related forms of the kinase Akt (1, 2, 3, also known as protein kinase B isoforms PKBα, β, γ) modulate cell proliferation, metabolism, and survival as well as angiogenesis. A-443654 is an inhibitor of Akt (Ki = 160 pmol/L for all three isoforms) that interferes with mitotic progression and bipolar spindle formation.1,2 It induces G2/M accumulation, defects in centrosome separation, and formation of either monopolar arrays or disorganized spindles.2 A-443654 has been reported to slow the progression of Akt-dependent tumors in in vivo mouse models.1 In response to an A-443654-induced decrease in phosphorylation of Akt targets, a concomitant increase in Thr308 and Ser473 phosphorylation of Akt has been observed in human cancer cell lines.3 A-443654 has been used to examine the mechanism of this rapid feedback reaction. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Luo, Y.,Shoemaker, A.R.,Liu, X., et al. Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Molecular Cancer Therapeutics 4(6), 977-968 (2005).
2.Liu, X.,Shi, Y.,Woods, K.W., et al. Akt inhibitor a-443654 interferes with mitotic progression by regulating aurora a kinase expression. Neoplasia 10(8), 828-837 (2008).
3.Han, E.K.,Leverson, J.D.,McGonigal, T., et al. Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene 26(38), 5655-5661 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 397.5 |
| 分子式 | C24H23N5O |
| CAS号 | 552325-16-3 |
| 稳定性 | ≥ 2 years |
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