GSA 10
货号：
16164-50mg 基本售价：
9520.0 元 规格：
50 mg
产品信息
概述| 货号 | 16164-50mg |
| 描述 | Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors.1 GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO.2 By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC50 = 1.2 µM).2 Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ruiz-Gómez, A.,Molnar, C.,Holguín, H., et al. The cell biology of Smo signalling and its relationships with GPCRs. Biochimica et Biophysica Acta 1768(4), 901-912 (2007).
2.Gorojankina, T.,Hoch, L.,Faure, H., et al. Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened. Molecular Pharmacology 83(5), 1020-1029 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 450.5 |
| 分子式 | C26H30N2O5 |
| CAS号 | 300833-95-8 |
| 稳定性 | ≥ 2 years |
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