| 货号 | 16105-10mg |
| 描述 | In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes. 5-Octyl-α-ketoglutarate, also known as α-ketoglutarate octyl ester, is a stable, cell-permeable molecule that generates free α-ketoglutarate upon hydrolysis of the ester bond by cytoplasmic esterases.1 It is used in experiments to increase levels of intracellular α-ketoglutarate.1 5-Octyl-α-ketoglutarate has been shown to modulate a variety of enzymes and signaling pathways, particularly in the context of glycolysis, hypoxia, and cancer.1,2,3,4,5 |
| 别名 | α-KG octyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.MacKenzie, E.D.,Selak, M.A.,Tennant, D.A., et al. Cell-permeating α-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Molecular and Cellular Biology 27(9), 3282-3289 (2007). 2.Xu, W.,Yang, H.,Liu, Y., et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell 19, 17-30 (2011). 3.Xiao, M.,Yang, H.,Xu, W., et al. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes & Development 26(12), 1326-1338 (2012). 4.Eckle, T.,Brodsky, K.,Bonney, M., et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLOS Biology 11(9), 1-25 (2013). 5.Chin, R.M.,Fu, X.,Pai, M.Y., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 509(7505), 397-401 (2014). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 258.3 |
| 分子式 | C13H22O5 |
| CAS号 | 1616344-00-3 |
| 稳定性 | ≥ 2 years |
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