| 货号 | 16009-100mg |
| 描述 | Salmeterol xinafoate is a long-acting, selective β2-adrenergic agonist with bronchodilator actions (EC50 = 0.25 µM) that has been used clinically to treat asthma and COPD.1,2,3 It demonstrates 2,818-fold selectivity for β2-adrenergic receptors over β1-adrenergic receptors.4 Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation.5 |
| 别名 | GR-33343G;Salmetedur;Serevent®; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Anderson, G.P. Formoterol: Pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective β2-adrenoceptor agonist bronchodilator. Life Sciences 52(26), 2145-2160 (1993). 2.Procopiou, P.A.,Barrett, V.J.,Ford, A.J., et al. The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea group. Bioorganic & Medicinal Chemistry 19(20), 6026-6032 (2011). 3.Tashkin, D.P. and Ferguson, G.T. Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease. Respiratory Research 14, 49 (2013). 4.Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005). 5.Isin, B.,Estiu, G.,Wiest, O., et al. Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probes. PLoS One 7(12), (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 603.8 |
| 分子式 | C25H27NO4 • C11H8O3 |
| CAS号 | 94749-08-3 |
| 稳定性 | ≥ 2 years |
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