| 货号 | 15037-50mg |
| 描述 | Mibefradil is a general calcium channel blocker that shows modest selectivity for T-type channels over L-type channels (IC50 = 2.7 and 18.6 μM, respectively).1,2,3 It is a potent vasodilator, increasing coronary artery flow with an EC50 value of 54 nM.2 Mibefradil has minimal negative inotropic effects, supporting its use as an anti-hypertensive agent.2,4 |
| 别名 | Posicor;Ro 40-5967; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bezprozvanny, I. and Tsien, R.W. Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967). Molecular Pharmacology 48(3), 540-549 (1995). 2.Osterrieder, W. and Holck, M. In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. Journal of Cardiovascular Pharmacology 13(5), 754-759 (1989). 3.Mehrke, G.,Zong, X.G.,Flockerzi, V., et al. The Ca++-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. Journal of Pharmacology and Experimental Therapeutics 271(3), 1483-1488 (1994). 4.Véniant, M.,Clozel, J.P.,Hess, P., et al. Hemodynamic profile of Ro 40-5967 in conscious rats: Comparison with diltiazem, verapamil, and amlodipine. Journal of Cardiovascular Pharmacology 18(10), S55-S58 (1991). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 568.6 |
| 分子式 | C29H38FN3O3 • 2HCl |
| CAS号 | 116666-63-8 |
| 稳定性 | ≥ 2 years |
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