Varenicline (tartrate)
货号：
15030-50mg 基本售价：
9520.0 元 规格：
50 mg
产品信息
概述| 货号 | 15030-50mg |
| 描述 | Varenicline is a partial agonist of the α4β2 neuronal nicotinic acetylcholine receptor (EC50 = 2.3 µM).1 It shows high selectivity for this receptor subclass relative to other nicotinic receptors, non-nicotinic receptors, and transporters. Varenicline competes with the binding of nicotine. It is effectively used in smoking cessation.2,3 |
| 别名 | CP 526,555-18; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mihalak, K.B.,Carroll, F.I. and Luetje, C.W. Varenicline is a partial agonist at α4β2 and a full agonist at α7 neuronal nicotinic receptors. Molecular Pharmacology 70(3), 801-805 (2006).
2.Mills, E.J.,Wu, P.,Lockhart, I., et al. Comparisons of high-dose and combination nicotine replacement therapy, varenicline, and bupropion for smoking cessation: A systematic review and multiple treatment meta-analysis. Annals of Medicine 44, 588-597 (2012).
3.Mineur, Y.S. and Picciotto, M.R. Nicotine receptors and depression: Revisiting and revising the chlorinergic hypothesis. Trends in Pharamacological Sciences 31(12), 580-586 (2010).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 361.4 |
| 分子式 | C13H13N3 • C4H6O6 |
| CAS号 | 375815-87-5 |
| 稳定性 | ≥ 2 years |
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