| 货号 | 11096-5mg |
| 描述 | Exendin-4 is a potent peptide agonist of the glucagon-like peptide 1 (GLP-1) receptor (Ki = 136 pM).1,2,3,4 By activating the GLP-1 receptor, it stimulates glucose-induced insulin secretion in isolated rat islets and proinsulin expression in mouse insulinoma βTC-1 cells, supporting efficacy in type 2 diabetes.2 Exendin-4 was first isolated from the venom of H. horridum and consequently synthesized, with the recombinant peptide referred to as ‘exenatide.’ Exenatide protects hippocampal neurons against glutamate-induced apoptosis, suggesting utility in neuropathies associated with type 2 diabetes and in neurodegenerative diseases.5,6 Exenatide also has anxiolytic and anti-depressant effects and induces satiety.6,7 |
| 别名 | Exenatide Acetate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Eng, J.,Kleinman, W.A.,Singh, L., et al. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. The Journal of Biological Chemisty 267(11), 7402-7405 (1992). 2.Göke, R.,Fehmann, H.C.,Linn, T., et al. Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells. The Journal of Biological Chemisty 268(26), 19650-19655 (1993). 3.Thorens, B.,Porret, A.,Bühler, L., et al. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42(11), 1678-1682 (1993). 4.Donnelly, D. The structure and function of the glucagon-like peptide-1 receptor and its ligands. British Journal of Pharmacology 166(1), 27-41 (2012). 5.Perry, T.,Haughey, N.J.,Mattson, M.P., et al. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. Journal of Pharmacology and Experimental Therapeutics 302(3), 881-888 (2002). 6.Komsuoglu Celikyurt, I.,Mutlu, O.,Ulak, G., et al. Exenatide treatment exerts anxiolytic- and antidepressant-like effects and reverses neuropathy in a mouse model of type-2 diabetes. Med.Sci.Monit.Basic Res. 20, 112-117 (2014). 7.van Bloemendaal, L.,Ten Kulve, J.S.,la Fleur, S.E., et al. Effects of glucagon-like peptide 1 on appetite and body weight: Focus on the CNS. Journal of Endocrinology 221(7), T1-T16 (2014). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 4246.6 |
| 分子式 | C184H282N50O60S • C2H4O2 |
| CAS号 | 914454-01-6 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |