| 货号 | 10008602-100ug |
| 描述 | Arachidonoyl ethanolamide (AEA) is an endogenous lipid neurotransmitter with cannabinergic activity, binding both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors.1,2 Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the hydrolysis and inactivation of AEA.3 Metabolism of AEA by cyclooxygenase-2, leading to formation of prostaglandin ethanolamides, and by lipoxygenases has also been documented.4 20-HETE ethanolamide is a potential cytochrome P450 metabolite of arachidonoyl ethanolamide, which may be particularly relevant under conditions of fatty acid amide hydrolase inhibition. Evidence for the formation of 20-HETE ethanolamide in vivo has not been documented. |
| 别名 | 20-hydroxy AEA;20-hydroxy Arachidonoyl Ethanolamide; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Felder, C.C.,Briley, E.M.,Axelrod, J., et al. Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. Proceedings of the National Academy of Sciences of the United States of America 90, 7656-7660 (1993). 2.Lambert, D.M., and Fowler, C.J. The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications. Journal of Medicinal Chemistry 48(16), 5059-5087 (2005). 3.Deutsch, D.G.,Ueda, N., and Yamamoto, S. The fatty acid amide hydrolase (FAAH). Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2&3), 201-210 (2002). 4.Kozak, K.R., and Marnett, L.J. Oxidative metabolism of endocannabinoids. Prostaglandins, Leukotrienes and Essential Fatty Acids 66(2&3), 211-220 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 363.5 |
| 分子式 | C22H37NO3 |
| CAS号 | 942069-11-6 |
| 稳定性 | ≥ 1 year |
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