| 货号 | 0821/50 |
| 别名 | (±)-erythro-(S*,S*)-1-[2,3-(Dihydro- |
| 供应商 | Tocris |
| 生物活性 | Very selective β2 adrenergic antagonist/inverse agonist (Ki values are 1.2, 120 and 257 nM for β2,β1andβ3 receptors respectively). Active in vivo. Also available as part of the β-Adrenoceptor Antagonist Tocriset™. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 313.87 |
| 分子式 | C17H27NO2.HCl |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO and to 10 mM in water |
| CAS号 | 72795-01-8 |
| 参考文献 | Strosberg and Pietri-Rouxel (1996) Function and regulation of the β3-adrenoceptor. TiPS 17 373. PMID: 8979772. Bondet al (1995) Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the β2-adrenoceptor. Nature 374 272. PMID: 7885448. Ten Bergeet al (1995) β2-but not β3-adrenoceptors mediate prejunctional inhibition of non-adrenergic non cholinergic contraction of guinea pig main bronchi. Eur.J.Pharmacol. 275 199. PMID: 7796855. Cooket al (1993) β-Adrenoceptor subtypes and the opening of plasmalemmal K+-channels in trachealis muscle: electrophysiological and mechanical studies in guinea-pig tissue. Br.J.Pharmacol. 109 1140. PMID: 8104643. Bilskiet al (1983) The pharmacology of a β2-selective adrenoceptor antagonist (ICI-118,551). J.Cardiovasc.Pharmacol. 5 430. PMID: 6191142. |