COX-2 (human recombinant)
货号：
60122-5kU 基本售价：
9450.0 元 规格：
5 Kunits
产品信息
概述| 货号 | 60122-5kU |
| 描述 | Cyclooxygenase 2 (COX-2) catalyzes the first step in the biosynthesis of prostaglandins (PGs), thromboxanes, and prostacyclins: The conversion fo arachidonic acid (Item No. 90010) to PGH2 (Item No. 17020). Discoveries of the induction of COX expression by a variety of stimuli such as phorbol esters, lipopolysaccharides, and cytokines led to the hypothesis that the inducible form of COX, COX-2, is responsible for the biosynthesis of PGs under acute inflammatory conditions.1 Thus, COX-2 has become the focus of attention for the nonsteroidal anti-inflammatory drug (NSAID) development. Human recombinant COX-2 contains a six residue histidine sequence (His-tag) near the amino terminus.2 The His-tag enzyme, which has a Km value for arachidonate of 6.5 µM, exhibits enzyme activity and sensitivity to NSAIDs similar to the non-tagged enzyme.2 |
| 别名 | Cyclooxygenase 2;Prostaglandin H Synthase 2; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Xie, W.,Chipman, J.G.,Robertson, D.L., et al. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. Proceedings of the National Academy of Sciences of the United States of America 88, 2692-2696 (1991).
2.Smith, T.,Leipprandt, J., and Dewitt, D. Purification and characterization of the human recombinant histidine-tagged prostaglandin endoperoxide H Synthases-1 and -2. Archives of Biochemistry and Biophysics 375, 195-200 (2000).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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