| 货号 | 17462-25mg |
| 描述 | 8-Prenylnaringenin (8-PN) is a prenylflavonoid with potent estrogenic activity that can be isolated from hops.1,2 It inhibits both isoforms of the human estrogen receptor (ER, IC50s = 57 and 68 nM for ERα and ERβ, respectively).3 8-PN is effective in vivo, suppressing loss of bone mineral density in ovariectomized rats and blocking changes in tail skin temperature in a rat model of postmenopausal hot flashes.4 |
| 别名 | Flavaprenin;8-PN; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Milligan, S.,Kalita, J.,Pocock, V., et al. Oestrogenic activity of the hop phyto-oestrogen, 8-prenylnaringenin. Reproduction 123, 235-242 (2002). 2.Hajirahimkhan, A.,Simmler, C.,Yuan, Y., et al. Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. PLoS One 8(7), e67947 (2013). 3.Roelens, F.,Heldring, N.,Dhooge, W., et al. Subtle side-chain modifications of the hop phytoestrogen 8-prenylnaringenin result in distinct agonist/antagonist activity profiles for estrogen receptors α and β. Journal of Medicinal Chemistry 49(25), 7357-7365 (2006). 4.Keiler, A.M.,Zierau, O., and Kretzschmar, G. Hop extracts and hop substances in treatment of menopausal complaints. Planta Medica 79, 576-579 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.4 |
| 分子式 | C20H20O5 |
| CAS号 | 53846-50-7 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |