| 货号 | 14414-5mg |
| 描述 | Caspase-3 is a cysteinyl aspartate-specific protease which plays a central role in apoptosis.1 Z-DEVD-FMK is a cell-permeable irreversible inhibitor of caspase-3 (IC50 = 130 nM).2,3 It potently inhibits apoptosis.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Granville, D.J.,Carthy, C.M.,Jiang, H., et al. Rapid cytochrome c release, activation of caspases 3, 6, 7, and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy. FEBS Letters 437, 5-10 (1998). 2.Brockstedt, E.,Rickers, A.,Kostka, S., et al. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. The Journal of Biological Chemisty 273(43), 28057-28064 (1998). 3.Lee, J. and Bogyo, M. Development of near-infrared fluorophore (NIRF)-labeled activity-based probes for in vivo imaging of legumain. ACS Chemical Biology 5(2), 233-243 (2010). 4.Kugawa, F.,Ueno, A. and Aoki, M. Apoptosis of NG108-15 cells induced by buprenorphine hydrochloride occurs via the caspase-3 pathway. Biological and Pharmaceutical Bullentin 23(8), 930-935 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 668.7 |
| 分子式 | C30H41FN4O12 |
| CAS号 | 210344-95-9 |
| 稳定性 | ≥ 2 years |
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